Genes of Roommates Can Influence Gut Microbiome: Study
The human microbiome, comprising trillions of microorganisms living within and around us, plays a vital role in our overall health and wellbeing. The gut microbiome, in particular, has been extensively studied for its impact on digestion, immune function, and even mental health. While factors such as diet, lifestyle, and environment are known to influence the gut microbiome, a recent study has made a groundbreaking discovery: the genes of individuals we live with can also have a significant impact on our gut bacteria.
Conducted in rats, the study found that three specific genetic regions can affect the composition of gut bacteria in individuals living together. One gene, St6galnac1, was found to be linked to higher levels of a sugar-feeding bacterium called Paraprevotella. This suggests that genetic effects can spread socially, indirectly influencing the health of others without the need for DNA exchange.
The study’s findings have significant implications for our understanding of the complex relationships between genetics, environment, and microbiome. It highlights the importance of considering the social context in which we live and how it can impact our health. For instance, if an individual lives with someone who has a genetic predisposition to a certain type of gut bacteria, they may be more likely to develop similar bacterial profiles, regardless of their own genetic makeup.
The study’s lead author noted that the discovery “challenges the traditional view of genetics as a solely individual-level trait.” Instead, it suggests that genetics can have a social component, where the genes of those around us can influence our own biology. This concept is often referred to as “social genetic effects” or “indirect genetic effects.”
To conduct the study, researchers used a novel approach called “genetic mapping of the microbiome.” This involved breeding rats with different genetic backgrounds and then housing them together in pairs. By analyzing the gut bacteria of each rat, the researchers were able to identify specific genetic regions that affected the composition of the microbiome.
The results showed that the genetic regions identified were associated with changes in the abundance of specific bacterial species. For example, the St6galnac1 gene was linked to an increase in Paraprevotella, a bacterium that feeds on sugars. This suggests that the genetic background of an individual can influence the types of bacteria that thrive in their gut, which can have implications for their overall health.
The study’s findings have significant implications for human health. For instance, if an individual lives with someone who has a genetic predisposition to a certain type of gut bacteria, they may be more likely to develop similar bacterial profiles. This could increase their risk of certain diseases, such as inflammatory bowel disease or obesity, which have been linked to alterations in the gut microbiome.
Furthermore, the study’s results highlight the importance of considering the social context in which we live. In today’s society, where people often live in close proximity to one another, the genetic effects of those around us can have a significant impact on our health. This is particularly relevant in cases where individuals live with family members or roommates who may have different genetic backgrounds.
The study’s lead author noted that the discovery “highlights the need for a more nuanced understanding of the interplay between genetics, environment, and microbiome.” By recognizing the social component of genetics, researchers can develop more effective strategies for promoting health and preventing disease.
In conclusion, the recent study on the genetic influence of roommates on gut microbiome has made a significant contribution to our understanding of the complex relationships between genetics, environment, and microbiome. The discovery that genetic effects can spread socially, indirectly influencing the health of others, highlights the importance of considering the social context in which we live. As we continue to explore the intricacies of the human microbiome, it is essential to recognize the role of genetics in shaping our bacterial profiles and the potential implications for our overall health.
Source:
https://www.sciencedaily.com/releases/2025/12/251223043938.htm
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