Common chemical used in plastics can feminise males & masculinise females, study finds
The world of plastics and food packaging has been under scrutiny for years due to the potential health risks associated with certain chemicals used in their production. One such chemical, Bisphenol A (BPA), has been a topic of concern among researchers and health experts. Recently, a study published in the journal Communications Medicine has shed new light on the effects of BPA on the development of males and females, particularly in the womb. The findings of this study are alarming, to say the least, and highlight the need for a deeper understanding of the impact of BPA on human health.
The study, which was conducted on mice, found that exposure to small amounts of BPA before birth can cause sex-specific changes in metabolism and the immune system. The researchers discovered that even very low doses of BPA can alter the expression of genes, leading to feminization of males and masculinization of females. This means that males exposed to BPA in the womb may develop characteristics that are typically associated with females, while females may exhibit traits that are typically masculine.
The study’s first author emphasized the significance of these findings, stating, “Even very low doses changed how the genes were expressed. Females were masculinised and males were feminised.” This suggests that the effects of BPA on development are not only significant but also occur at very low levels of exposure. The fact that BPA can alter gene expression and lead to sex-specific changes in metabolism and the immune system is a cause for concern, particularly given the widespread use of BPA in plastics and food packaging.
BPA is a chemical compound that is commonly used to make plastics and is found in a variety of consumer products, including food and water containers, baby bottles, and dental materials. It is also used in the lining of metal food cans and in some paper products, such as receipts and tickets. BPA can leach into food and water, particularly when containers are heated or damaged, and has been detected in the urine of nearly all humans tested.
The study’s findings have significant implications for human health, particularly for pregnant women and their developing fetuses. Exposure to BPA during pregnancy has been linked to a range of health problems, including birth defects, reproductive issues, and developmental delays. The fact that BPA can alter gene expression and lead to sex-specific changes in metabolism and the immune system suggests that exposure to this chemical during critical periods of development may have long-lasting effects on health.
The researchers behind the study are calling for a re-evaluation of the safety of BPA and its use in consumer products. They argue that the current regulatory framework, which allows for the use of BPA in certain products, may not be sufficient to protect human health. The study’s authors are advocating for a more precautionary approach to the use of BPA, particularly in products that are designed for use by pregnant women and children.
The findings of this study also highlight the need for further research into the effects of BPA on human health. While the study was conducted on mice, the results suggest that similar effects may occur in humans. Further studies are needed to fully understand the impact of BPA on human development and health, particularly in relation to sex-specific changes in metabolism and the immune system.
In conclusion, the study’s findings are a wake-up call for regulators, manufacturers, and consumers alike. The fact that BPA can feminize males and masculinize females, even at very low doses, is a cause for concern and highlights the need for a more cautious approach to the use of this chemical in consumer products. As we continue to learn more about the effects of BPA on human health, it is essential that we take steps to minimize exposure to this chemical, particularly during critical periods of development.
News Source: https://www.uu.se/en/news/2025/2025-10-27-bisphenol-a-causes-sex-specific-changes-in-metabolism-and-the-immune-system
About the Author
